Lisa Bertrand, Emmanuel Labaronne et al Pub: Nature Communications
A second study, published in Nature Communicationscontributed by Emmanuel Labaronne of ADLIN Science and the LBMC RMI2 team, identifies 98 new alternative reading frames (ARFs) encoding previously unknown viral polypeptides.
These discoveries could reorient vaccine strategies by highlighting new conserved antigens as potential targets. This breakthrough is essential for a better understanding of viral evolution and the development of new therapeutic approaches against HIV-1.
ADLIN Science is proud to contribute to this research by providing its expertise in the advanced analysis of translational and multi-omics data. By combining bioinformatics and modeling approaches, we are helping to discover key biological mechanisms in virology and immunology.
This study follows an initial publication demonstrating how HIV-1 uses non-AUG uORFs to produce small immunogenic peptides. Taken together, this work provides new insight into the translational regulation of HIV-1!
Find out more about the first study here:
🔗 HIV-1 exploitation of uORFs: a novel immunogenic mechanism!
